03 JUN

How to prevent this disease Can families who have children with MMA still have children?

  • Health Fitness
  • Jean
  • Mar 31,2022
  • 22

How to prevent this disease Can families who have children with MMA still have children?

1. Avoid marrying close relatives.

2. Newborn screening: inherited metabolic disorders Newborn screening is very important for early detection and treatment.

Screening by tandem mass spectrometry of dried blood filter paper after 3 days of life (at least 6-8 breastfeeding sessions) can lead to early diagnosis and treatment, reduce mortality and disability rates, and understand the local prevalence of MMA.

Prenatal diagnosis: Families who have already had a child with MMA and want to get pregnant again can consult with the prenatal diagnosis department.

Reproductive guidance and prenatal diagnosis are key measures to reduce the number of births in patients with genetic metabolic disease.

Fetal diagnosis can be performed through genetic analysis if the cause of the disease is clear and the genetic diagnosis is clear.

Methylmalonic acid, propionylcarnitine, total homocysteine and amniotic fluid cytogenetic analysis are reliable techniques for prenatal diagnosis of MMA.

Newborn screening for genetic metabolic disorders is essential! It allows screening for congenital and genetic disorders that are life-threatening, developmentally dangerous, or cause mental retardation in children.

This allows for early screening, early diagnosis and early treatment of the disease.

For parents who have already given birth to a child with a genetic metabolic disease, non-genetic metabolic disease embryos can be selected through three generations of IVF, provided that the cause of the disease is clear and the genetic diagnosis is clear;

Fetal diagnosis can be made through biochemical or genetic analysis to avoid the birth of a lethal child; screening and early treatment after birth are key.